Know the signs of thyroid eye disease
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QUALITY-OF-LIFE ISSUES Not all the challenges of thyroid eye disease are physical. According to a survey of physicians treating TED, patients find it difficult to function in social
situations, with about a third experiencing anxiety and/or depression. Problems with the alignment of the eyes and double vision, in particular, can affect the quality of life. “Double
vision can knock you out of commission — you can’t drive or do normal activities,” Winokur says. “And there are people who are in constant pain from dry eye. They use eye drops and get
relief for five minutes, then go on the computer and can’t work.” Fortunately, help is available. The Graves’ Disease and Thyroid Foundation offers resources and online support groups for
those suffering with thyroid eye disease, including at onegravesvoice.com. EASING EYE DISCOMFORT A doctor who suspects you have Graves’ eye disease will first examine your thyroid for
abnormalities. If an overactive thyroid is the cause, your doctor will make sure it’s controlled with antithyroid medications. Graves’ disease and thyroid eye disease share a similar biology
— both are caused by the immune system’s attack on healthy tissue — yet one doesn’t necessarily cause the other. TED can occur when thyroid levels are high, normal or low. For those with
mild TED, slipping on a pair of sunglasses may help with light sensitivity. Adding prisms to your glasses may do away with double vision, too. Irritation can be managed with cool compresses,
artificial tears and an eye gel at night. “If the eye is pushed forward and more prominent, you can’t close your lid properly when you’re asleep,” Pearce says. “A lubricating gel can
protect the surface of the eye.” Be wary of over-the-counter eye drops — the FDA has recalled dozens of brands in stores and on Amazon for the risk of temporary or permanent vision
problems. (If you can’t get prescription eye drops, read “How to Find Safe Eye Drops Amid FDA Warnings” before making a purchase.) The FDA’s website also regularly posts recall notices. And
if you’re a smoker, consider this one more reason to stop: Smokers with Graves’ disease are about twice as likely to develop TED as those who don’t smoke, and smoking makes TED worse. GUT
HEALTH AND TED Multiple studies have shown that gut dysfunction could fuel Graves’ disease and TED. Many studies, including one published in the _Journal of Clinical Endocrinology and
Metabolism_, have shown an imbalance in two key types of gut bacteria that could contribute to the development of the disease. This supports decades of research that suggests gut dysfunction
is a “leg” that helps prop up the “stool” (or “triad”) of autoimmunity. Whether prebiotics or probiotics might correct this imbalance and help decrease TED needs more research, but at least
one large analysis showed a modest effect on reducing the antibody thought to be responsible for TED. However, adding specific foods to your diet may also help to improve gut health. Some
are foods rich in galactooligosaccharides (GOS; a type of prebiotic often found in foods with lactose) and fiber, which could help strengthen the gut. To get more GOS in your diet, try
these healthy alternatives to full-fat milk and butter: * Lentils * Greek yogurt * Kefir * Chickpeas To get more fiber in your diet, try these nutrient-dense foods: * Raspberries * Green
peas * Quiona (cooked) * Split peas For even more tips to boost your fiber intake, read “8 Ways to Get More Fiber in Your Diet.” Selenium, a mineral mainly found in grains and nuts, may
also be helpful. “If a patient’s diet is poor in selenium, we may recommend that they eat Brazil nuts, which have a high amount of selenium,” Pearce says. “It’s also an antioxidant, so it
helps with inflammation in the eyes. Or we may give them a mineral supplement with selenium in it.” NONSURGICAL TREATMENTS CORTICOSTEROIDS. For more aggressive symptoms, your doctor may
suggest corticosteroids (particularly prednisone) to reduce inflammation. “Eyes that are inflamed — lots of redness, watering and tearing, swelling of the eyelids or the whites of the eye,
and grittiness — can be treated very nicely with steroids,” Pearce says. TEPEZZA. Another option is Tepezza, FDA approved in 2020 as the first prescription medication to treat TED. It’s
given via an IV in your arm every three weeks for a total of eight times. Tepezza stops the growth of the muscles and soft tissue behind the eye to reduce eye bulging, double vision and
pain. It’s promising, for sure, but you’ll want to talk to your doctor. For one thing, there may be side effects. (Recently, more than half the participants of a small study experienced
hearing loss to varying degrees after being treated.) And there’s the jaw-dropping price tag: Tepezza is estimated to cost at least $17,929 for one vial. Insurance coverage and patient
out-of-pocket costs vary, depending on insurance plans. SURGICAL TREATMENTS Ultimately, even after TED is under control, people may need rehabilitative surgery to correct the appearance of
their eyes and return them to their previous shape. ORBITAL DECOMPRESSION SURGERY. Performed when pressure on the optic nerve is threatening vision. An endoscope is carefully maneuvered
through the nose and the sinus near the eyes, and pieces of bone and tissue are removed to give the eye more room to fall back into place. “It also reduces some of the compression around the
optic nerve,” says Winokur. A pair of outpatient procedures, performed using local anesthesia, can tackle other problems. EYE MUSCLE SURGERY. Performed when scar tissue, which forms around
eye muscles, becomes stiff, causing eyes to become misaligned and leading to double vision. A surgeon repositions the muscles, bringing eyes into alignment. EYELID REPOSITIONING SURGERY.
Performed when the muscles of the eyelids are too tight, causing the eyelids to open too widely. Eyelid muscles or tendons are released, allowing the eyelid to return to a more natural
position. Even after corrective surgeries are completed, you may be left with some unwelcome souvenirs “because your eyelids swell up with inflammation and fluid, and because you probably
rub them a lot,” says Pearce. “That stretches the skin. People are often left with saggy, baggy eyes.” Swollen and puffy tissue around the eye can be tightened with blepharoplasty (more
commonly known as an eye lift). Laser resurfacing and injections, such as Restylane, can give saggy skin a boost.