Profile of primary resistance in hiv-1-infected treatment-naive individuals from western india
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PROFILE OF PRIMARY RESISTANCE IN HIV-1-INFECTED TREATMENT-NAIVE INDIVIDUALS FROM WESTERN INDIA CONTENTS * Abstract * Citation * Links ABSTRACT The majority of the HIV drug resistance (HIVDR)
testing studies have focused on subtype B virus. The predominance of subtype C in the Indian subcontinent along with greater access to antiretroviral therapy (ART) necessitates studies on
HIVDR genotyping. We determined the prevalence of mutations associated with protease inhibitors (PI), nucleoside reverse transcriptase inhibitors (NRTI), and nonnucleoside reverse
transcriptase inhibitors (NNRTI) from plasma of 40 antiretroviral drug-naive study participants in Indian HIV-1 pol gene sequences. Of these, 36 sequences belonged to subtype C, two to
subtype A1, and two were subtype A1C recombinants. The heterosexual route was the most common route of transmission. Drug resistance-associated mutations were observed in 10% (4/40) of the
study participants. The resistance mutation observed in the protease gene was V82A, whereas in the RT gene, M41L, D67N, M184V, and A98G were documented. This is the first study reporting
major protease mutations by genotyping in ART-naive individuals from western India. CITATION Lall, M.; Gupta, R.M.; Sen, S.; Kapila, K.; Tripathy, S.P.; Paranjape, R.S. Profile of Primary
Resistance in HIV-1-Infected Treatment-Naive Individuals from Western India. AIDS Research and Human Retroviruses (2008) 24 (7) 987-990. [DOI: 10.1089/aid.2008.0079] LINKS * aid.2008.0079 *
Lall.2008.ARHR.pdf UPDATES TO THIS PAGE Published 1 January 2008 Contents