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ABSTRACT We have identified a novel protein, BAP1, which binds to the RING finger domain of the Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a nuclear-localized,

ubiquitin carboxy-terminal hydrolase, suggesting that deubiquitinating enzymes may play a role in BRCA1 function. BAP1 binds to the wild-type BRCA1-RING finger, but not to germline mutants

of the BRCA1-RING finger found in breast cancer kindreds. _BAP1_ and _BRCA1_ are temporally and spatially co-expressed during murine breast development and remodeling, and show overlapping

patterns of subnuclear distribution. _BAP1_ resides on human chromosome 3p21.3; intragenic homozgyous rearrangements and deletions of BAP1 have been found in lung carcinoma cell lines. BAP1

enhances BRCA1-mediated inhibition of breast cancer cell growth and is the first nuclear-localized ubiquitin carboxy-terminal hydrolase to be identified. _BAP1_ may be a new tumor suppressor

gene which functions in the BRCA1 growth control pathway. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS THE DEUBIQUITINATING ENZYME USP4 REGULATES BRCA1 STABILITY AND FUNCTION Article

Open access 11 May 2024 ROLES AND MECHANISMS OF BAP1 DEUBIQUITINASE IN TUMOR SUPPRESSION Article 18 January 2021 SUPERCHARGING BRD4 WITH NUT IN CARCINOMA Article 15 January 2021 AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * The Wistar Institute, 3601 Spruce Street, Philadelphia, 19104, Pennsylvania, USA David E Jensen, Alexander M Ishov, David C Schultz, Gerd G Maul, 

Nickolai Barlev, Shelley L Berger, George C Prendergast & Frank J Rauscher III * Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas,

75235, Texas, USA Monja Proctor, Yoshitaka Sekido & John Minna * Denmark and The Department of Medical Genetics, John F. Kennedy Institute, 2600 Glostrup, The Panum Institute, University

of Copenhagen, Copenhagen, DK2200, Denmark Niels Tommerup * Department of Molecular Genetics, Novo Nordisk, Bagsvaerd, DK-2880, Denmark Henrik Vissing * Department of Biochemistry, Emory

University, Atlanta, 30322, Georgia, USA Anna Borodovsky & Keith D Wilkinson * Department of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine,

Philadelphia, 19104, Pennsylvania, USA Sandra T Marquis, Heather Perry Gardner, Seung I Ha & Lewis A Chodosh Authors * David E Jensen View author publications You can also search for

this author inPubMed Google Scholar * Monja Proctor View author publications You can also search for this author inPubMed Google Scholar * Sandra T Marquis View author publications You can

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publications You can also search for this author inPubMed Google Scholar * Lewis A Chodosh View author publications You can also search for this author inPubMed Google Scholar * Alexander M

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can also search for this author inPubMed Google Scholar * Gerd G Maul View author publications You can also search for this author inPubMed Google Scholar * Nickolai Barlev View author

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Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jensen, D., Proctor, M., Marquis, S. _et al._ BAP1: a novel ubiquitin hydrolase which

binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. _Oncogene_ 16, 1097–1112 (1998). https://doi.org/10.1038/sj.onc.1201861 Download citation * Received: 16

January 1998 * Revised: 26 January 1998 * Accepted: 27 January 1998 * Published: 10 March 1998 * Issue Date: 05 March 1998 * DOI: https://doi.org/10.1038/sj.onc.1201861 SHARE THIS ARTICLE

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by the Springer Nature SharedIt content-sharing initiative KEYWORDS * ubiquitin hydrolase * BRCA1 * chromosome 3p21.3 * RING finger