Capturing the onset of the common cold and its effects on iron absorption


Capturing the onset of the common cold and its effects on iron absorption

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ABSTRACT Hypoferremia is a well-known response to infections and inflammatory disorders. It seems to be managed by the key mediator of iron kinetics, hepcidin. There are several studies on


induced-acute phase reactions. However, to our best knowledge there are no previous published reports on the outbreak of a common cold and its initial effect on iron kinetics. The objective


of this case report is to describe such an observation. From an apparently healthy state in the morning we observed, in a 28-year-old male, every hour for 6 h the outbreak of a common cold


and the modulations in the levels of serum iron (S-Fe) and interleukin-6 (IL-6). Despite a 100 mg oral iron loading there was a substantial reduction in S-Fe, which seemed to precede the


IL-6 peak. Interestingly, this observed succession is in conflict with the proposed infection chain of order in which IL-6 stimulates hepcidin induction. Access through your institution Buy


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RITUXIMAB-CONTAINING THERAPY FOR COLD AGGLUTININ DISEASE: A RETROSPECTIVE STUDY OF 16 PATIENTS Article Open access 29 July 2020 REFERENCES * Beresford CH, Neale RJ, Brooks OG (1971). Iron


absorption and pyrexia. _Lancet_ 1, 568–572. Article  CAS  Google Scholar  * Berger D, Bolke E, Seidelmann M, Beger HG (1997). Time-scale of interleukin-6, myeloid related proteins (MRP), C


reactive protein (CRP), and endotoxin plasma levels during the postoperative acute phase reaction. _Shock_ 7, 422–426. Article  CAS  Google Scholar  * Birgegard G, Hallgren R, Killander A,


Stromberg A, Venge P, Wide L (1978). Serum ferritin during infection. A longitudinal study. _Scand J Haematol_ 21, 333–340. Article  CAS  Google Scholar  * Blade J, Filella X, Montoto S,


Bosch F, Rosinol L, Coca F _et al_. (2002). Interleukin 6 and tumour necrosis factor alpha serum levels in monoclonal gammopathy of undetermined significance. _Br J Haematol_ 117, 387–389.


Article  CAS  Google Scholar  * Brambilla F, Monti D, Franceschi C (2001). Plasma concentrations of interleukin-1-beta, interleukin-6 and tumor necrosis factor-alpha, and of their soluble


receptors and receptor antagonist in anorexia nervosa. _Psychiatry Res_ 103, 107–114. Article  CAS  Google Scholar  * Ekenved G, Norrby A, Solvell L (1976). Serum iron increase as a measure


of iron absorption - studies on the correlation with total absorption. _Scand J Haematol Suppl_ 28, 31–49. CAS  PubMed  Google Scholar  * Elin RJ, Wolff SM, Finch CA (1977). Effect of


induced fever on serum iron and ferritin concentrations in man. _Blood_ 49, 147–153. CAS  PubMed  Google Scholar  * Eskeland B, Baerheim A, Ulvik R, Hunskaar S (2002). Influence of mild


infections on iron status parameters in women of reproductive age. _Scand J Prim Health Care_ 20, 50–56. Article  Google Scholar  * Fattori E, Cappelletti M, Costa P, Sellitto C, Cantoni L,


Carelli M _et al_. (1994). Defective inflammatory response in interleukin 6-deficient mice. _J Exp Med_ 180, 1243–1250. Article  CAS  Google Scholar  * Feelders RA, Vreugdenhil G, Eggermont


AM, Kuiper-Kramer PA, van Eijk HG, Swaak AJ (1998). Regulation of iron metabolism in the acute-phase response: interferon gamma and tumour necrosis factor alpha induce hypoferraemia,


ferritin production and a decrease in circulating transferrin receptors in cancer patients. _Eur J Clin Invest_ 28, 520–527. Article  CAS  Google Scholar  * Hoppe M, Hulthén L, Hallberg L


(2003). Serum iron concentration as a tool to measure relative iron absorption from elemental iron powders. _Scand J Clin Lab Invest_ 63, 489–496. Article  CAS  Google Scholar  * Hoppe M,


Hulthén L, Hallberg L (2006). The relative bioavailability in humans of elemental iron powders for use in food fortification. _Eur J Nutr_ 45, 37–44. Article  CAS  Google Scholar  * Hulthen


L, Lindstedt G, Lundberg PA, Hallberg L (1998). Effect of a mild infection on serum ferritin concentration--clinical and epidemiological implications. _Eur J Clin Nutr_ 52, 376–379. Article


  CAS  Google Scholar  * Kemna EH, Pickkers P, Nemeth E, Van der Hoeven H, Swinkels D (2005). Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with


LPS. _Blood_ 106, 1864–1866. Article  CAS  Google Scholar  * Lee P, Peng H, Gelbart T, Wang L, Beutler E (2005). Regulation of hepcidin transcription by interleukin-1 and interleukin-6.


_Proc Natl Acad Sci USA_ 102, 1906–1910. Article  CAS  Google Scholar  * Meffert M, Hanninen EL, Menzel T, Schomburg A, Duensing S, Dallmann I _et al_. (1994). _In vivo_ time and dose


dependency of interleukin-6 secretion in response to low-dose subcutaneous recombinant interleukin-2. _Cancer Biother_ 9, 307–316. Article  CAS  Google Scholar  * Roy CN, Andrews NC (2005).


Anemia of inflammation: the hepcidin link. _Curr Opin Hematol_ 12, 107–111. Article  CAS  Google Scholar  * Walsh BW, Cox DA, Sashegyi A, Dean RA, Tracy RP, Anderson PW (2001). Role of tumor


necrosis factor-alpha and interleukin-6 in the effects of hormone replacement therapy and raloxifene on C-reactive protein in postmenopausal women. _Am J Cardiol_ 88, 825–828. Article  CAS


  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Clinical Nutrition, Institute of Internal Medicine, the Sahlgrenska Academy at Göteborg


University, Gothenburg, Sweden M Hoppe & L Hulthén Authors * M Hoppe View author publications You can also search for this author inPubMed Google Scholar * L Hulthén View author


publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to M Hoppe. ADDITIONAL INFORMATION _Guarantor_: M Hoppe. RIGHTS AND PERMISSIONS


Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hoppe, M., Hulthén, L. Capturing the onset of the common cold and its effects on iron absorption. _Eur J Clin Nutr_ 61,


1032–1034 (2007). https://doi.org/10.1038/sj.ejcn.1602614 Download citation * Received: 26 July 2006 * Revised: 15 November 2006 * Accepted: 15 November 2006 * Published: 31 January 2007 *


Issue Date: August 2007 * DOI: https://doi.org/10.1038/sj.ejcn.1602614 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link


Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * iron * serum iron


concentration * interleukin-6 * infection * inflammation * hepcidin