Meta-analysis of serotonin transporter gene promoter polymorphism (5-httlpr) association with selective serotonin reuptake inhibitor efficacy in depressed patients


Meta-analysis of serotonin transporter gene promoter polymorphism (5-httlpr) association with selective serotonin reuptake inhibitor efficacy in depressed patients

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ABSTRACT The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not


consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate, response rate and response rate within 4


weeks using the cochrane review manager. We observed a significant association of the s/s variant of 5-HTTLPR with remission rate (_P_<0.0001) and both s/s and s/l variants with response


rate (_P_=0.0002). Response rate within 4 weeks was associated in both models (_P_=0.003–_P_<0.00001). This effect is quite robust to ethnic differences although a significant


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BETWEEN THE 1438A/G, 102T/C, AND RS7997012G/A POLYMORPHISMS OF HTR2A AND THE SAFETY AND EFFICACY OF ANTIDEPRESSANTS IN DEPRESSION: A META-ANALYSIS Article 23 October 2020 REFERENCES *


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references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Institute of Psychiatry, University of Bologna, Bologna, Italy A Serretti, M Kato & D De Ronchi * Department of Neuropsychiatry,


Kansai Medical University, Osaka, Japan M Kato & T Kinoshita Authors * A Serretti View author publications You can also search for this author inPubMed Google Scholar * M Kato View


author publications You can also search for this author inPubMed Google Scholar * D De Ronchi View author publications You can also search for this author inPubMed Google Scholar * T


Kinoshita View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to A Serretti. RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Serretti, A., Kato, M., De Ronchi, D. _et al._ Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with


selective serotonin reuptake inhibitor efficacy in depressed patients. _Mol Psychiatry_ 12, 247–257 (2007). https://doi.org/10.1038/sj.mp.4001926 Download citation * Received: 26 July 2006 *


Revised: 31 August 2006 * Accepted: 25 September 2006 * Published: 05 December 2006 * Issue Date: 01 March 2007 * DOI: https://doi.org/10.1038/sj.mp.4001926 SHARE THIS ARTICLE Anyone you


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Springer Nature SharedIt content-sharing initiative KEYWORDS * depression * meta-analysis * 5-HTTLPR * polymorphism * treatment response * SSRI