Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum


Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum

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ABSTRACT We measured tumour cellular DNA in 102 patients entered into two phase III trials of chemotherapy for end stage squamous carcinoma of the head and neck. The median survival of


untreated patients with aneuploid tumours was 55 days compared with 224 days for patients treated with cisplatinum. This difference was highly significant. In contrast the median survival of


untreated patients with diploid tumours was 74 days compared with 118 days for treated patients. Although this difference is statistically significant, the increased survival of 6 weeks is


of no clinical benefit compared with the prolongation of survival of 6 months in patients with aneuploid tumours. Multivariate analysis showed that the significant predictors of survival


were Karnofsky status, response to chemotherapy and ploidy. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS


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PROGNOSTICATE PATIENT OUTCOMES Article Open access 30 December 2024 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Otorhinolaryngology, University of Liverpool, UK LD Cooke


Authors * LD Cooke View author publications You can also search for this author inPubMed Google Scholar * TG Cooke View author publications You can also search for this author inPubMed 


Google Scholar * F Bootz View author publications You can also search for this author inPubMed Google Scholar * G Forster View author publications You can also search for this author


inPubMed Google Scholar * TR Helliwell View author publications You can also search for this author inPubMed Google Scholar * D Spiller View author publications You can also search for this


author inPubMed Google Scholar * PM Stell View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS


ARTICLE CITE THIS ARTICLE Cooke, L., Cooke, T., Bootz, F. _et al._ Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum.


_Br J Cancer_ 61, 759–762 (1990). https://doi.org/10.1038/bjc.1990.169 Download citation * Issue Date: 01 May 1990 * DOI: https://doi.org/10.1038/bjc.1990.169 SHARE THIS ARTICLE Anyone you


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