Inhibition of angiogenesis and murine tumour growth by laminarin sulphate
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ABSTRACT LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart
endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and
inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01). Access through your
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BEING VIEWED BY OTHERS ROBUSTAFLAVONE INDUCES G0/G1 CELL CYCLE ARREST AND APOPTOSIS IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS AND EXHIBITS ANTI-ANGIOGENIC EFFECTS IN VIVO Article Open access
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VASCULAR ENDOTHELIAL GROWTH FACTOR A Article 25 July 2023 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, UK R Hoffman
Authors * R Hoffman View author publications You can also search for this author inPubMed Google Scholar * DH Paper View author publications You can also search for this author inPubMed
Google Scholar * J Donaldson View author publications You can also search for this author inPubMed Google Scholar * H Vogl View author publications You can also search for this author
inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hoffman, R., Paper, D., Donaldson, J. _et al._ Inhibition of angiogenesis and
murine tumour growth by laminarin sulphate. _Br J Cancer_ 73, 1183–1186 (1996). https://doi.org/10.1038/bjc.1996.228 Download citation * Issue Date: 01 May 1996 * DOI:
https://doi.org/10.1038/bjc.1996.228 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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