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ABSTRACT CD4+ T-cell functions that best correlate with CMV control were evaluated by studying the relationship between CMV infection and CMV-specific immune recovery as determined by

proliferation assay and intracytoplasmic-IFNγ assay. A total of 30 children (mean age: 8.30 years) who received an allogeneic hematopoietic SCT (HSCT) were included. In total, 13 recipients

were seronegative before HSCT. None developed CMV infection or CMV-specific immunity. A total of 17 recipients were seropositive: (i) four patients spontaneously controlled CMV. The median

of CMV-specific IFNγ-secreting CD4 T cells was 9.13/μl at month 3 in these four patients and three of the four patients evidenced optimal proliferative responses since month 1; (ii) in 10

patients who received anti-CMV chemotherapy because of prolonged viremia, lower (_P_=0.016) IFNγ responses (0.39/μl), together with delayed and/or depressed proliferative responses, were

observed; (iii) finally, one patient with early CMV-associated disease had undetectable proliferative and IFNγ responses until month 3. In conclusion, both intense IFNγ responses and early

proliferative responses seem to be associated with optimal CMV control. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS SAFETY AND EFFICACY OF THE LOW-DOSE MEMORY (CD45RA-DEPLETED) DONOR

LYMPHOCYTE INFUSION IN RECIPIENTS OF ΑΒ T CELL-DEPLETED HAPLOIDENTICAL GRAFTS: RESULTS OF A PROSPECTIVE RANDOMIZED TRIAL IN HIGH-RISK CHILDHOOD LEUKEMIA Article 16 February 2021 COMPARABLE

ANTI-CMV RESPONSES OF TRANSPLANT DONOR AND THIRD-PARTY CMV-SPECIFIC T CELLS FOR TREATMENT OF CMV INFECTION AFTER ALLOGENEIC STEM CELL TRANSPLANTATION Article 11 January 2022 THE ROLE OF

GRAFT T-CELL SIZE IN PATIENTS RECEIVING ALEMTUZUMAB SEROTHERAPY FOR NON-MALIGNANT DISORDERS: RESULTS OF AN INSTITUTIONAL PROTOCOL Article Open access 10 January 2024 REFERENCES * Bunde T,

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Download references ACKNOWLEDGEMENTS We thank the clinical team for patient care, Guylaine Boiry, Anne-Marie Courchinoux, Elodie Geneletti and Ingrid Hamon for excellent technical assistance

and Céline Neto for typing the manuscript and drawing the figures. This work was supported by Assistance Publique—Hôpitaux de Paris and University Paris VII, France. AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Université Paris VII, Paris, France V Guérin, B Pédron & G Sterkers *

Department of Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Université Paris VII, Paris, France J-H Dalle, M Ouachée-Chardin, K Yakouben & A Baruchel Authors *

V Guérin View author publications You can also search for this author inPubMed Google Scholar * J-H Dalle View author publications You can also search for this author inPubMed Google

Scholar * B Pédron View author publications You can also search for this author inPubMed Google Scholar * M Ouachée-Chardin View author publications You can also search for this author

inPubMed Google Scholar * K Yakouben View author publications You can also search for this author inPubMed Google Scholar * A Baruchel View author publications You can also search for this

author inPubMed Google Scholar * G Sterkers View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to G Sterkers. RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Guérin, V., Dalle, JH., Pédron, B. _et al._ Cellular immune parameters associated with spontaneous control of CMV

in children who underwent transplantation. _Bone Marrow Transplant_ 45, 442–449 (2010). https://doi.org/10.1038/bmt.2009.179 Download citation * Received: 11 March 2009 * Revised: 29 May

2009 * Accepted: 10 June 2009 * Published: 27 July 2009 * Issue Date: March 2010 * DOI: https://doi.org/10.1038/bmt.2009.179 SHARE THIS ARTICLE Anyone you share the following link with will

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content-sharing initiative KEYWORDS * immune-recovery * cytomegalovirus * hematopoietic-stem cell transplantation * children