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ABSTRACT Metabolic Syndrome (MS) is recognized as a cluster of cardiovascular risk factors. All components of MS have a genetic base. Genes of the renin angiotensin system are potential

candidate genes for MS. We investigated whether angiotensin converting enzyme (ACE) gene polymorphism increases susceptibility to MS as an entity in a Mexican population. In a

cross-sectional study, 514 individuals were studied including 245 patients with MS and 269 subjects without MS criteria. ACE gene polymorphism was detected using PCR. MS was defined

according to The National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) criteria, except

that the raised fasting plasma glucose ≥ 100 mg/dl criterion for identification of intolerance fasting glucose was modified in accordance with the suggestion of the American Diabetes

Association. Patients with MS were significantly different from subjects without MS in relation to mean body mass index (BMI), waist circumference (WC), systolic blood pressure, diastolic

blood pressure, glucose, total cholesterol (C), triglycerides, HDL-C, and LDL-C (P<0.0001). The differences in the mean BMI, WC, glucose, total cholesterol, triglycerides, LDL-C, and

HDL-C were maintained in patients with the MS and DD genotypes (P<0.01). The DD genotype was strongly associated with MS (adjusted OR=5.48, 95% CI 3.20-9.38, P<0.0001). We concluded

that the DD genotype increases susceptibility to MS in a Mexican population. These results indicate that pharmacological and non-pharmacological treatment and a reduction in body fat will

have important therapeutic implications in this disease. SIMILAR CONTENT BEING VIEWED BY OTHERS GENETIC VARIATIONS IN _ACE2_ GENE ASSOCIATED WITH METABOLIC SYNDROME IN SOUTHERN CHINA: A

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LESIONS Article Open access 07 June 2024 INFLUENCE OF BLOOD PRESSURE POLYGENIC RISK SCORES AND ENVIRONMENTAL FACTORS ON CORONARY ARTERY DISEASE IN THE KOREAN GENOME AND EPIDEMIOLOGY STUDY

Article 20 November 2023 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Unidad de Investigacion en Epidemiologia Clinica, Hospital General Regional No. 1, Morelia, Michoacan,

Mexico Cleto Alvarez-Aguilar Authors * Cleto Alvarez-Aguilar View author publications You can also search for this author inPubMed Google Scholar * Maria Lucia Enriquez-Ramirez View author

publications You can also search for this author inPubMed Google Scholar * Benigno Figueroa-Nunez View author publications You can also search for this author inPubMed Google Scholar * Anel

Gomez-Garcia View author publications You can also search for this author inPubMed Google Scholar * Ernesto Rodriguez-Ayala View author publications You can also search for this author

inPubMed Google Scholar * Cristina Moran-Moguel View author publications You can also search for this author inPubMed Google Scholar * Victor Manuel Farias-Rodriguez View author publications

You can also search for this author inPubMed Google Scholar * Dolores Mino-Leon View author publications You can also search for this author inPubMed Google Scholar * Joel Edmundo

Lopez-Meza View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS This is an Open Access article distributed under the terms of the

Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any

medium, provided the original work is properly cited. Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Alvarez-Aguilar, C., Enriquez-Ramirez, M., Figueroa-Nunez, B. _et al._

Association between angiotensin-1 converting enzyme gene polymorphism and the metabolic syndrome in a Mexican population. _Exp Mol Med_ 39, 327–334 (2007).

https://doi.org/10.1038/emm.2007.36 Download citation * Published: 01 June 2007 * Issue Date: 01 June 2007 * DOI: https://doi.org/10.1038/emm.2007.36 SHARE THIS ARTICLE Anyone you share the

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Nature SharedIt content-sharing initiative KEYWORDS * metabolic syndrome X * obesity * peptidyl-dipeptidase A * polymorphism, genetic * renin-angiotensin system * risk factors