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ABSTRACT Inflammation of the asthmatic airway is usually accompanied by increased vascular permeability and plasma exudation. Angiopoietin-1 (Ang1) has potential therapeutic applications in

preventing vascular leakage. Recently, we developed a soluble, stable, and potent Ang1 variant, COMP-Ang1. COMP-Ang1 is more potent than native Ang1 in phosphorylating the tyrosine kinase

with immunoglobulin and epidermal growth factor homology domain 2 receptor in lung endothelial cells. We have used a mouse model for allergic airway disease to determine effects of COMP-Ang1

on allergen-induced bronchial inflammation and airway hyper-responsiveness. These mice develop the following typical pathophysiological features of allergic airway disease in the lungs:

increased numbers of inflammatory cells of the airways, airway hyper-responsiveness, increased levels of Th2 cell cytokines (IL-4, IL-5, and IL-13), adhesion molecules (intercellular

adhesion molecule-1 and vascular cell adhesion molecule-1), and chemokines (eotaxin and RANTES), and increased vascular permeability. Intravenous administration of COMP-Ang1 reduced

bronchial inflammation and airway hyper-responsiveness. In addition, the increased plasma extravasation in allergic airway disease was significantly reduced by the administration of

COMP-Ang1. These results suggest that COMP-Ang1 attenuates airway inflammation and hyper-responsiveness, prevents vascular leakage, and may be used as a therapeutic agent in allergic airway

disease. SIMILAR CONTENT BEING VIEWED BY OTHERS A MONOCLONAL ANTIBODY TO SIGLEC-8 SUPPRESSES NON-ALLERGIC AIRWAY INFLAMMATION AND INHIBITS IGE-INDEPENDENT MAST CELL ACTIVATION Article Open

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September 2023 EOSINOPHIL-DERIVED CHEMOKINE (HCCL15/23, MCCL6) INTERACTS WITH CCR1 TO PROMOTE EOSINOPHILIC AIRWAY INFLAMMATION Article Open access 28 February 2021 ARTICLE PDF AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Department of Internal Medicine, Airway Remodeling Laboratory, Chonbuk National University Medical School, Jeonju, 561-180, Korea Kyung Sun Lee Authors

* Kyung Sun Lee View author publications You can also search for this author inPubMed Google Scholar * Ka Young Lee View author publications You can also search for this author inPubMed 

Google Scholar * So Ri Kim View author publications You can also search for this author inPubMed Google Scholar * Hee Sun Park View author publications You can also search for this author

inPubMed Google Scholar * Seoung Ju Park View author publications You can also search for this author inPubMed Google Scholar * Kyung Hoon Min View author publications You can also search

for this author inPubMed Google Scholar * Chung-Hyun Cho View author publications You can also search for this author inPubMed Google Scholar * Gou Young Koh View author publications You can

also search for this author inPubMed Google Scholar * Ho Sung Park View author publications You can also search for this author inPubMed Google Scholar * Yong Chul Lee View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS This is an Open Access article distributed under the terms of the Creative Commons Attribution

Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original

work is properly cited. Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lee, K., Lee, K., Kim, S. _et al._ Blockade of airway inflammation and hyper-responsiveness by an

angiopoietin-1 variant, COMP-Ang1. _Exp Mol Med_ 39, 733–745 (2007). https://doi.org/10.1038/emm.2007.80 Download citation * Published: 01 December 2007 * Issue Date: 01 December 2007 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * angiopoietin-1 * asthma * capillary permeability *

receptor, Tie-2