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ABSTRACT The anti-diabetic effect of cytogenin was examined using streptozotocin-induced diabetes in mice. Cytogenin suppressed not only the increase of plasma glucose level but also the

body weight reduction in diabetic mice. Histological examination of the pancreas taken from diabetic mice given cytogenin showed that cytogenin decreased the number of macrophages

infiltrated into islet of pancreas. Further, cytogenin suppressed the nitric oxide generation by macrophages treated with lipopolysaccharide through decreasing of inducible nitric oxide

synthase expression. Cytogenin suppressed interleukin-6 expression by macrophage treated with LPS, suggesting that the anti-diabetic activity of cytogenin might be partly attributed to the

suppressive activity against nitric oxide generation. SIMILAR CONTENT BEING VIEWED BY OTHERS COMPARATIVE IMPACT OF STREPTOZOTOCIN ON ALTERING NORMAL GLUCOSE HOMEOSTASIS IN DIABETIC RATS

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SILICO STUDY Article Open access 05 February 2025 _LEIURUS QUINQUESTRATUS_ VENOM PROMOTES Β ISLETS REGENERATION AND RESTORES GLUCOSE LEVEL IN STREPTOZOTOCIN INDUCED TYPE 2 DIABETES MELLITUS

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references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Numazu Bio-Medical Research Institute, Microbial Chemistry Research Foundation, 18-24 Miyamoto, Numazu, Shizuoka, 410-0301, Japan

Hiroyuki Kumagai, Masaaki Ishizuka & Daishiro Ikeda * Bioresource Laboratories, Mercian Co. Ltd., 1808 Nakaizumi, Iwata, Shizuoka, 438-0078, Japan Kuniko Wakazono, Naoki Agata & 

Kunio Isshiki Authors * Hiroyuki Kumagai View author publications You can also search for this author inPubMed Google Scholar * Kuniko Wakazono View author publications You can also search

for this author inPubMed Google Scholar * Naoki Agata View author publications You can also search for this author inPubMed Google Scholar * Kunio Isshiki View author publications You can

also search for this author inPubMed Google Scholar * Masaaki Ishizuka View author publications You can also search for this author inPubMed Google Scholar * Daishiro Ikeda View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Daishiro Ikeda. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Kumagai, H., Wakazono, K., Agata, N. _et al._ Effect of Cytogenin, a Novel Immunomodulator, on Streptozotocin-induced Diabetes in Mice. _J Antibiot_ 58, 202–205

(2005). https://doi.org/10.1038/ja.2005.24 Download citation * Received: 12 October 2004 * Accepted: 07 February 2005 * Issue Date: 01 March 2005 * DOI: https://doi.org/10.1038/ja.2005.24

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * cytogenin * streptozotocin * diabetes * macrophage * nitric oxide * inducible nitric oxide *

interleukin-6