Reply to Explaining the biological activity of transactivation-deficient p53 variants
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Our laboratory recently generated conditional Trp53 knock-in mice in which codons 25 and 26 were mutated to glutamine and serine (QS) to address the role of transactivation in p53 function1.
Our Trp53QS mice have a different phenotype from those described by Wahl and colleagues2, which also carry a mutation in the DNA binding domain at codon 135 (Trp53QS-Val135)3. Our analysis
of Trp53QS mice demonstrates that this mutant retains select p53 activities. In contrast, Wahl and colleagues show that the Trp53QS-Val135 allele behaves indistinguishably from a Trp53-null
allele.
p53 QS-wt effects on embryogenesis in relation to wild-type p53 (PDF 320 kb)
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