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ABSTRACT The expression of the _FMR–1_ gene, which is implicated in fragile–X syndrome was investigated in human fetuses by _in situ_ hybridization. In 8 and 9 week–old fetuses, _FMR–1_

mRNAs are expressed in proliferating and migrating cells of the nervous system, in the retina, and in several non–nervous tissues. In the brain of 25 week–old fetuses, _FMR–1_ mRNAs are

produced in all nearly differenciated structures, with the highest level in cholinergic neurons of the nucleus basalis magnocellularis and in pyramidal neurons of hippocampus. The early

transcription of _FMR–1_ gene and the distribution of _FMR–1_ mRNAs in human fetuses suggest that alterations of _FMR–1_ gene expression may contribute to the pathogenesis of fragile–X

syndrome and especially the mental retardation. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS THE MOLECULAR BIOLOGY OF FMRP: NEW INSIGHTS INTO FRAGILE X SYNDROME Article 19 February 2021 A

HUMAN FOREBRAIN ORGANOID MODEL OF FRAGILE X SYNDROME EXHIBITS ALTERED NEUROGENESIS AND HIGHLIGHTS NEW TREATMENT STRATEGIES Article 19 August 2021 REDUCED AXONAL CALIBER AND STRUCTURAL

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AFFILIATIONS * Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs CNRS, 1 avenue de la Terrasse, 91198, Gif-sur-Yvette, France Marc Abitbol, 

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ARTICLE Abitbol, M., Menini, C., Delezoide, AL. _et al._ Nucleus basalis magnocellularis and hippocampus are the major sites of _FMR-1_ expression in the human fetal brain. _Nat Genet_ 4,

147–153 (1993). https://doi.org/10.1038/ng0693-147 Download citation * Received: 30 November 1992 * Accepted: 09 February 1993 * Issue Date: 01 June 1993 * DOI:

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