News Reader.info

Infusion of aging monkeys with growth hormone promotes proliferation of mammary epithelia, suggesting caution in treating the elderly with growth hormone supplements (pages 1141–1144).

Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this

journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now

Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer

support REFERENCES * Rudman, D. _et al_. Effects of human growth hormone on body composition in elderly men. _Horm. Res._ 36 (Suppl. 1), 73–81 (1991). Article  Google Scholar  * Gelato, M.C.

Aging and immune function: A possible role for growth hormone. _Horm. Res._ 45, 46–49 (1996). Article  CAS  Google Scholar  * Toogood, A.A., O'Neill, P.A. & Shalet, S.M. Beyond the

somatopause: Growth hormone deficiency in adults over the age of 60 years. _J. Clin. Endocrinol. Metab._ 81, 460–465 (1996). CAS  PubMed  Google Scholar  * Ghiron, L.J. _et al_. Effects of

recombinant insulin-like growth factor-l and growth hormone on bone turnover in elderly patients. _J. Bone Miner. Res._ 10, 1844–1852 (1995). Article  CAS  Google Scholar  * Thompson, J.L.

_et al_. The effects of recombinant human insulin-like growth factor-l and growth hormone on body composition in elderly patients. _J. Clin. Endocrinol. Metab._ 80, 1845–1852 (1995). CAS 

PubMed  Google Scholar  * Welle, S., Thornton, C., Statt, M. & McHenry, B. Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in

healthy subjects over 60 years old. _J. Clin. Endocrinol. Metab._ 81, 3239–3243 (1996). CAS  PubMed  Google Scholar  * Ng, S.T. _et al_. Growth hormone treatment induces mammary gland

hyperplasia in aging primates. _Nature Med._ 3, 1141–1144 (1997). Article  CAS  Google Scholar  * De León, D.D., Powers, M., Wilson, D.M. & Rosenfeld, R.G. Effects of insulin-like growth

factors (IGFs) and IGF receptor antibodies in human breast cancer Cell proliferation. _Growth Factors_ 6, 327–336 (1992). Article  Google Scholar  * Stoll, B.A. Growth hormone and breast

cancer. _Clinical Oncolog_ 4, 4–5 (1992). Article  CAS  Google Scholar  * Yang, X.F., Beamer, W.G., Huynh, H. & Pollack, M. Reduced growth of human breast cancer xenografts in hosts

homozygous for the _lit_ mutation. _Cancer. Res._ 56, 1509–1511 (1996). CAS  PubMed  Google Scholar  * Moll, J.A., Van Garderen, E., Rutteman, G.R. & Rijnberk, A. New insights into the

molecular mechanism of progestin-induced proliferation of mammary epithelium: induction of the local biosynthesis of growth hormone (GH) in the mammary glands of dogs, cats and humans. _J.

Steroid Biochem. Mol. Biol._ 57, 67–71 (1996). Article  Google Scholar  * Decouvelaere, C., Peyrat, J.P., Bonneterre, J., Djiane, J. & Jammes, H. Presence of the two growth hormone

receptor messenger RNA iso-forms in human breast cancer. _Cell Growth Differ._ 4, 477–483 (1995). Google Scholar  * Van Farderen, E. _et al_. Expression of GH in canine mammary tissue and

mammary tumors. Evidence for a potential autocrine/paracrine stimulatory loop. _Am. J. Pathol._ 150, 1037–1047 (1997). Google Scholar  * Mauras, N., Martha, P.M., Quarmby, V. & Haymond,

M.W. rhIGF-l administration in humans: Differential metabolic effects of bolus vs. continuous subcutaneous delivery. _Am. J. Physiol._ 272, E628–E633 (1997). Article  CAS  Google Scholar 

Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California, 92350, USA Daisy D. De leon *

Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois, 61801, USA Sharon M. Donovan Authors * Daisy D. De leon View author publications You can also search

for this author inPubMed Google Scholar * Sharon M. Donovan View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE De leon, D., Donovan, S. Is breast cancer a potential side effect of GH treatment?. _Nat Med_ 3, 1081–1082 (1997).

https://doi.org/10.1038/nm1097-1081 Download citation * Issue Date: 01 October 1997 * DOI: https://doi.org/10.1038/nm1097-1081 SHARE THIS ARTICLE Anyone you share the following link with

will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt

content-sharing initiative