Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
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Aberrations in proteins that control apoptosis and cell survival are common in cancer. These aberrations often reside in signalling proteins that control the activation of the apoptotic
machinery or in the Bcl-2 family of proteins that control caspase activation. Recent evidence suggests that caspase 2, one of the most evolutionarily conserved caspases, may have multiple
roles in the DNA damage response, cell cycle regulation and tumour suppression. These findings are unexpected and have important implications for our understanding of tumorigenesis and the
treatment of cancer.
I thank Donna Denton, Martin Lavin and Loretta Dorstyn for helpful comments. The work in my laboratory is supported by the National Health and Medical Research Council of Australia and the
Cancer Council of South Australia.
Department of Haematology, Sharad Kumar is at the Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, SA5000, Australia. [email protected],
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