Mapping metabolites—specific metabolic signatures in urine are associated with adiposity
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A specific pattern of metabolites detectable in urine samples is associated with increased BMI according to new data published in Science Translational Medicine. Using an exploratory
metabolic phenotyping approach, investigators have identified how different groups of metabolites interact to create a 'metabolic signature' of adiposity.
In their analysis, Elliot et al. used the 24-h urine samples collected from 1,880 individuals from the USA (962 men and 918 women). These samples were analysed by both high-resolution NMR
spectroscopy and ion-exchange chromatography to identify excreted metabolites; these findings correlated with BMI calculated from original height and weight data. The investigators then
validated these data using identically collected urine samples from 444 participants from the UK (245 men and 199 women).
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