Gut microbiota produce alcohol in patients with nash


Gut microbiota produce alcohol in patients with nash

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Access through your institution Buy or subscribe Previous data from this group revealed that global gene expression in livers from patients with NASH was distinct from that of healthy


livers. Interestingly, although dietary alcohol intake was similar, the expression of all genes involved in alcohol metabolism was greater in NASH livers than healthy livers. “We concluded


that the only possible source of alcohol in patients with NASH was the gut microbiome,” says Zhu. The aim of this study was simple: identify and quantitate the microbial species in the gut


of obese patients with NASH, and compare them with those identified in the gut of obese patients without NASH and healthy individuals as controls. The investigators pyrosequenced 16S rRNA


extracted from the gut microbiota of these patients and healthy controls. Alcohol concentration in the circulation was also determined. This is a preview of subscription content, access via


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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in


* Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Zhu, L. _ et al_. Characterization of the gut microbiome in non-alcoholic


steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. _Hepatology_ doi:10.1002/hep.26093 Download references Authors * Katherine Smith View author publications


You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Smith, K. Gut microbiota produce alcohol in


patients with NASH. _Nat Rev Gastroenterol Hepatol_ 9, 687 (2012). https://doi.org/10.1038/nrgastro.2012.209 Download citation * Published: 13 November 2012 * Issue Date: December 2012 *


DOI: https://doi.org/10.1038/nrgastro.2012.209 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is


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