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Access through your institution Buy or subscribe The recent finding that a gain-of-function polymorphism in the gene encoding TSLP is associated with the development of EoE led the authors

to investigate the role of this cytokine in the disease. They generated a disease model in which mice were first sensitized to a food allergen — ovalbumin (OVA) — through the skin, using the

vitamin D analogue MC903 or tape-stripping to generate a lesion, and were then orally challenged with OVA. Similar to the disease in humans, mice that were sensitized and challenged with

OVA developed inflammation and eosinophilia in the oesophagus. This EoE-like disease was associated with increased TSLP expression in the skin and oesophageal tissues, as well as with high

levels of mRNA encoding T helper 2-type cytokines and a basophil-specific protease. Further analysis showed that 30% of mice with the disease had impacted food in the oesophagus at the time

of killing, whereas food impaction was never observed in control mice. To explore the involvement of TSLP in this mouse model of EoE, the authors first studied TSLP receptor

(TSLPR)-deficient mice. Unlike wild-type mice, _Tslpr_−/− mice did not develop oesophageal eosinophilia following sensitization and challenge with OVA. In further support of a necessary and

sufficient role for TSLP, it was shown that EoE-like disease developed after oral challenge when wild-type mice were sensitized to OVA in the presence of recombinant TSLP, but not when they

were treated with OVA alone. Interestingly, although the EoE-like disease was associated with high levels of OVA-specific IgE, IgE-deficient and IgE-sufficient mice developed equivalent

diseases, which suggests that the disease is IgE independent. This is consistent with reports that indicate that IgE-targeted therapies fail to ameliorate EoE in most patients. This is a

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Noti, M. et al. Thymic stromal

lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. _Nature Med._ 19, 1005–1013 10.1038/nm.3281 (2013) Article  CAS  PubMed  Google Scholar  Download references

Authors * Lucy Bird View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Bird, L. Basophils make food hard to swallow. _Nat Rev Immunol_ 13, 619 (2013). https://doi.org/10.1038/nri3518 Download citation * Published: 02 August 2013 * Issue Date: September 2013 *

DOI: https://doi.org/10.1038/nri3518 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

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