Inhibiting initiation — targeting bmi1 is effective
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Access through your institution Buy or subscribe Inhibition of polycomb complex protein BMI-1 (BMI1) in prostate self-renewing tumour-initiating cells (TICs) with small-molecule
post-transcriptional inhibitors reduces colony formation _in vitro_ and tumour initiation _in vivo_, according to new data published in _Clinical Cancer Research_. Thus, targeting BMI1 in
TICs could be an effective strategy for treating prostate cancer. BMI1 regulates stem cell self renewal, has a key role in prostate cancer initiation and progression, and its downstream
targets are associated with therapy resistance. Bansal and collegues show that expression of BMI1 is increased in prostate cancer cell lines and that downregulation of BMI1 _in vitro_ is
associated with decreased cell motility, clonogenic capacity, and survival, providing a rationale for targeting this protein. This is a preview of subscription content, access via your
institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this
article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in
* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Bansal, N. _ et al_. BMI-1 targeting interferes with patient-derived tumor-initiating cell
survival and tumor growth in prostate cancer. _Clin. Cancer Res._ http://dx.doi.org/10.1158/1078-0432.CCR-15-3107 (2016) Download references Authors * Louise Stone View author publications
You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Stone, L. Inhibiting initiation — targeting
BMI1 is effective. _Nat Rev Urol_ 13, 436 (2016). https://doi.org/10.1038/nrurol.2016.131 Download citation * Published: 05 July 2016 * Issue Date: August 2016 * DOI:
https://doi.org/10.1038/nrurol.2016.131 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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