Glucose-induced calciuria in dogs


Glucose-induced calciuria in dogs

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ABSTRACT In human subjects, glucose (G) ingestion results in a prompt increase in urinary calcium excretion (CE). It has been suggested (Lindeman et al., J Lab Clin Med 70:236, 1967) that G


utilization by the kidney is involved in this calciuric effect, but no direct evidence is available in this regard. In the present study, dogs fed G (1.5g/kg) had 1.5 to 5-fold increases in


CE and 1.4 to 3-fold increases in urine calcium concentrations. Increased CE began within 30 minutes and continued during the 2 hours of observation. Plasma G did not rise above 111


mg/100ml, and there was no glycosuria. The dog thus appeared a suitable model for studying G-induced calciuria. The possibility of a direct renal effect of G was investigated by infusing G


into the left renal arteries of anesthetized hypophysectomized dogs. CE increased only with infusion rates great enough to cause glycosuria and marked natriuresis. Lower infusion rates did


not affect CE. These findings do not rule out a role for renal G metabolism in G-induced calciuria, since hormonal consequences of a G meal (e.g., insulin release) could affect renal


carbohydrate metabolism. But an alternative possibility would be an indirect effect not involving renal G utilization. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Univ. Calif,


at Davis, Sch. Med., Depts. of Ped., Physiol., Surg. Julian J Irias, Thomas C Lee, Makepeace U Tsao, Walter H Hamilton, Larry Hein & Robert E Greenberg Authors * Julian J Irias View


author publications You can also search for this author inPubMed Google Scholar * Thomas C Lee View author publications You can also search for this author inPubMed Google Scholar *


Makepeace U Tsao View author publications You can also search for this author inPubMed Google Scholar * Walter H Hamilton View author publications You can also search for this author


inPubMed Google Scholar * Larry Hein View author publications You can also search for this author inPubMed Google Scholar * Robert E Greenberg View author publications You can also search


for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Irias, J., Lee, T., Tsao, M. _et al._ GLUCOSE-INDUCED CALCIURIA


IN DOGS. _Pediatr Res_ 8, 433 (1974). https://doi.org/10.1203/00006450-197404000-00561 Download citation * Issue Date: 01 April 1974 * DOI: https://doi.org/10.1203/00006450-197404000-00561


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