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ABSTRACT BPD may be due to lung connective tissue damage caused by oxidants and proteolytic enzymes in prematures with RDS who are treated with ventilators and oxygen. Antiproteases, such as

AAT, may protect the lungs against this destruction. To study its potential role we measured plasma trypsin inhibitory capacity (TIC) (Erlanger method) in 27 prematures who required

ventilator therapy for treatment of RDS. Day 1 TIC values were significant ly lower (p<0.0001) in the 13 patients who developed BPD when compared to the 14 who did not, other significant

variables included birthweight (p<.0.005), severity of RDS (p<0.03) and gestational age (p<0.05). One way analysis of variance demonstrated day 1 TIC to be the most significant

variable (p<0.00001) followed by birth weight (p<0.0175), severity of RDS (p<0.058) and gestational age (p<0.0739). A composite of these 4 variables (TIC, birth weight, severity

RDS and gestational age), were 100% sensitive and 86% specific in the prediction of BPD. Decreased TIC on day 1 may be of pathogenetic and prognostic significance in the development of BPD.

ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Interfaith Medical Center, SUNY/Downstate Medical Center, Brooklyn, New York Warren Rosenfeld, Luz

Concepcion, Ignacio Zabaleta, Ramesh Jhaveri & Hugh Evans Authors * Warren Rosenfeld View author publications You can also search for this author inPubMed Google Scholar * Luz Concepcion

View author publications You can also search for this author inPubMed Google Scholar * Ignacio Zabaleta View author publications You can also search for this author inPubMed Google Scholar

* Ramesh Jhaveri View author publications You can also search for this author inPubMed Google Scholar * Hugh Evans View author publications You can also search for this author inPubMed 

Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Rosenfeld, W., Concepcion, L., Zabaleta, I. _et al._ 1822 ALPHA 1 ANTITRYPSIN IN THE

PREDICTION OF BRONCHOPULMONARY DYSPLASIA (BPD). _Pediatr Res_ 19, 414 (1985). https://doi.org/10.1203/00006450-198504000-01840 Download citation * Issue Date: 01 April 1985 * DOI:

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