ENHANCED EFFICACY OF VIRA-A, ACYCLOVIR IN COMBINATION WITH BETA INTERFERON IN HERPES SIMPLEX INFECTIONS
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1. The efficacy of a single antiviral drug Vira-A, Acyclovir, Beta Interferon native and recombinant as compaired to a combination of two antiviral drugs acyclovir and Beta Interferon was
evaluated in experimental herpes keratitis in rabbits. As a single antiviral drug acyclovir ointment promoted the most rapid epitelization time, but during the treatment period virus
‘escapes’ were detected. The best results were obtlaned with a combination of Beta Interferon and acyclo vir demonstrating the potentiation of the antiviral activity of acyclovir by Beta
Interferon. 2. In human herpes keratitis the combination of Beta Interferon and acyclovir resulted in a rapid epitelization time, short virus shedding time and no relapse during a subsequent
18 month observation period. 3. In human herpes labialis the combination of Beta Interferon and acyclovir resulted in a shortening of the disease to a 1/3 of the usual period. Prophylactic
Beta Interferon ointment when only numbling was felt prevented the appearance of vesicles on the lips. 4. In Herpes Zoster when started early in the disease the combination of acyclovir and
Beta Interferon resulted in a shortening of disease and rapid dissappearance of pain.
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