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Nuclear speckles are dynamic structures enriched in RNA and RNA regulators, with varying compositions. A study now reports two distinct signatures of nuclear speckles that are linked to the

prognosis of clear cell renal cell carcinoma. The signatures influence the expression of genes regulated by the transcription factor HIF2α. Access through your institution Buy or subscribe

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  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan Hiro Takakuwa & Tetsuro Hirose Authors * Hiro

Takakuwa View author publications You can also search for this author inPubMed Google Scholar * Tetsuro Hirose View author publications You can also search for this author inPubMed Google

Scholar CORRESPONDING AUTHOR Correspondence to Tetsuro Hirose. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Takakuwa, H., Hirose, T. Speckle signatures dictate cancer prognosis. _Nat Cell Biol_ 27, 180–181 (2025).

https://doi.org/10.1038/s41556-024-01569-7 Download citation * Published: 03 January 2025 * Issue Date: February 2025 * DOI: https://doi.org/10.1038/s41556-024-01569-7 SHARE THIS ARTICLE

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