Combining radiolabelled therapies for neuroendocrine neoplasms
- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN

Play all audios:

Neuroendocrine liver metastases often require multiple modes of treatment to attain disease control, which can utilize various forms of radiolabelled agents either delivered systemically or
preferentially towards the liver. A recent trial suggested both safety and efficacy of a novel approach of combining the two to provide a radiation ‘boost’ to hepatic deposits. Access
through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other
Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online
access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which
are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Frilling, A. et al.
Recommendations for management of patients with neuroendocrine liver metastases. _Lancet Oncol._ 15, e8–21 (2014). Article Google Scholar * Dasari, A. et al. Trends in the incidence,
prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. _JAMA Oncol._ 3, 1335–1342 (2017). Article Google Scholar * Chen, J. X. et al. Embolotherapy
for neuroendocrine tumor liver metastases: prognostic factors for hepatic progression-free survival and overall survival. _Cardiovasc. Intervent. Radiol._ 40, 69–80 (2017). Article Google
Scholar * Kratochwil, C. et al. Hepatic arterial infusion enhances DOTATOC radiopeptide therapy in patients with neuroendocrine liver metastases. _Endocr. Relat. Cancer_ 18, 595–602 (2011).
Article CAS Google Scholar * Kennedy, A. et al. Role of hepatic intra-arterial therapies in metastatic neuroendocrine tumours (NET): guidelines from the NET-Liver-Metastases Consensus
Conference. _HPB_ 17, 29–37 (2015). Article Google Scholar * Frilling, A. et al. Radioembolisation with 90Y microspheres for neuroendocrine liver metastases: an institutional case series,
systematic review and meta-analysis. _HPB_ 21, 773–783 (2019). Article Google Scholar * Braat, A. J. A. T. et al. Additional holmium-166 radioembolisation after lutetium-177-dotatate in
patients with neuroendocrine tumour liver metastases (HEPAR PLuS): a single-centre, single-arm, open-label, phase 2 study. _Lancet Oncol._ 21, 561–570 (2020). Article CAS Google Scholar *
Strosberg, J. et al. Phase 3 Trial of 177Lu-dotatate for midgut neuroendocrine tumors. _N. Engl. J. Med._ 376, 125–135 (2017). Article CAS Google Scholar * Pavel, M. et al. ENETS
consensus guidelines update for the management of distant metastatic disease of intestinal, pancreatic, bronchial neuroendocrine neoplasms (NEN) and NEN of unknown primary site.
_Neuroendocrinology_ 103, 172–185 (2016). Article CAS Google Scholar * Kennedy, A. et al. Safety of selective internal radiation therapy (SIRT) with yttrium-90 microspheres combined with
systemic anticancer agents: Expert consensus. _J. Gastrointest. Oncol._ 8, 1079–1099 (2017). Article Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *
Department of Surgery & Cancer, Imperial College London, London, UK Andrea Frilling & Ashley Kieran Clift * NHS Nightingale Hospital London, London, UK Ashley Kieran Clift Authors *
Andrea Frilling View author publications You can also search for this author inPubMed Google Scholar * Ashley Kieran Clift View author publications You can also search for this author
inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Andrea Frilling. ETHICS DECLARATIONS COMPETING INTERESTS A.F. reports receiving speaker honoraria from SIRTEX. A.K.C. declares
no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Frilling, A., Clift, A.K. Combining radiolabelled therapies for neuroendocrine
neoplasms. _Nat Rev Endocrinol_ 16, 347–348 (2020). https://doi.org/10.1038/s41574-020-0367-3 Download citation * Published: 07 May 2020 * Issue Date: July 2020 * DOI:
https://doi.org/10.1038/s41574-020-0367-3 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative