Dexamethasone in patients with diabetes mellitus
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Patients with COVID-19 who require supplemental oxygen and/or mechanical ventilation are routinely treated with dexamethasone. However, glucocorticoids can exacerbate dysglycaemia, and the
benefits of dexamethasone treatment in patients with diabetes mellitus were unclear. A retrospective analysis has assessed data from the first two waves of the COVID-19 pandemic in the UK.
Mortality was reduced in the second wave compared with the first wave, with dexamethasone being independently associated with reduced risk of admission to the intensive care unit and/or
death. Furthermore, a multivariate analysis demonstrated that the independent effect size of dexamethasone was similar for patients with and without diabetes mellitus. The authors conclude
that dexamethasone is beneficial for patients with severe COVID-19 and diabetes mellitus, but that treatment guidelines need to incorporate strategies to identify and manage steroid-induced
hyperglycaemia. REFERENCES ORIGINAL ARTICLE * Eng, P. C. et al. The benefit of dexamethasone in patients with COVID-19 infection is preserved in patients with diabetes. _Diabetes Obes.
Metab._ https://doi.org/10.1111/dom.14692 (2022) Article PubMed Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Endocrinology
http://www.nature.com/nrendo/ Claire Greenhill Authors * Claire Greenhill View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR
Correspondence to Claire Greenhill. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Greenhill, C. Dexamethasone in patients with diabetes mellitus. _Nat
Rev Endocrinol_ 18, 333 (2022). https://doi.org/10.1038/s41574-022-00676-5 Download citation * Published: 12 April 2022 * Issue Date: June 2022 * DOI:
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