A new diagnostic marker for alzheimer disease?


A new diagnostic marker for alzheimer disease?

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Access through your institution Buy or subscribe Elevated β-synuclein levels in the cerebrospinal fluid (CSF) could be an early indicator of Alzheimer disease (AD), according to new


research. Using a novel ELISA, researchers detected increased CSF β-synuclein levels in patients with mild cognitive impairment, AD dementia or Creutzfeldt–Jakob disease, but not in other


neurological conditions such as Parkinson disease and amyotrophic lateral sclerosis. β-Synuclein localizes to glutamatergic synapses in the brain, and its presence in the CSF could be an


early sign of AD-associated synaptic degeneration. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54


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Halbgebauer, S. et al. Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer’s disease. _J. Neurol. Neurosurg. Psychiatry_ https://doi.org/10.1136/jnnp-2020-324306


(2020) Article  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Neurology http://www.nature.com/nrneurol/ Heather Wood Authors *


Heather Wood View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Heather Wood. RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wood, H. A new diagnostic marker for Alzheimer disease?. _Nat Rev Neurol_ 17, 64 (2021). https://doi.org/10.1038/s41582-021-00458-z Download


citation * Published: 11 January 2021 * Issue Date: February 2021 * DOI: https://doi.org/10.1038/s41582-021-00458-z SHARE THIS ARTICLE Anyone you share the following link with will be able


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