Car t cells induce remission in a patient with refractory sle
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Access through your institution Buy or subscribe Chimeric antigen receptor (CAR) T cell therapy has been used to treat a patient with systemic lupus erythematosus (SLE) for the first time.
The immunotherapy approach, which is already approved for use in the treatment of some types of cancer, induced rapid clinical remission of severe and refractory disease with no notable
adverse effects. The 20-year-old female patient underwent leukapheresis and preparatory lymphodepleting chemotherapy before receiving an infusion of autologous CAR T cells that had been
genetically engineered to recognize the B cell surface antigen CD19. Following the infusion, the CD19 CAR T cells expanded in vivo, increasing from 0.31% of total circulating T cells at day
3 to 27.69% at day 9, and remained detectable during the subsequent 7 weeks. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
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REFERENCES ORIGINAL ARTICLE * Mougiakakos, D. et al. CD19-targeted CAR T cells in refractory systemic lupus erythematosus. _N. Engl. J. Med._ 385, 567–569 (2021) Article Google Scholar
RELATED ARTICLE * Kansal, R. et al. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. _Sci. Transl Med._ 11, eaav1648 (2019) Article
Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology http://www.nature.com/nrrheum/ Sarah Onuora Authors * Sarah Onuora View author
publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Sarah Onuora. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS
ARTICLE CITE THIS ARTICLE Onuora, S. CAR T cells induce remission in a patient with refractory SLE. _Nat Rev Rheumatol_ 17, 579 (2021). https://doi.org/10.1038/s41584-021-00691-2 Download
citation * Published: 01 September 2021 * Issue Date: October 2021 * DOI: https://doi.org/10.1038/s41584-021-00691-2 SHARE THIS ARTICLE Anyone you share the following link with will be able
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