Retraction Note: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
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Retraction of: Nature https://doi.org/10.1038/nature14492 Published online 27 May 2015
The Editors have retracted this paper because, in their view, data in Extended Data Fig. 1d and Extended Data Fig. 4a are unreliable. Issues with the original antibody used in Extended Data
Fig. 1d and 4a have been identified. The western blots showing an increase in secreted LOX in bone-trophic and hypoxic MDA-MB-231 cells, and shRNA knockdown of LOX in 4T1 cells, present
unreliable bands. R.L. agrees with the retraction. All other authors disagree with the retraction and believe the findings are still valid.
These authors contributed equally: Alison Gartland & Janine T. Erler
Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Copenhagen, Denmark
Thomas R. Cox, Lara Perryman, Anette M. Høye, Rune Linding & Janine T. Erler
Hypoxia and Metastasis Team, Cancer ResearchUKTumour Cell Signalling Unit, The Institute of Cancer Research, London, UK
Thomas R. Cox, Demelza Bird, Georgina Lang & Janine T. Erler
The Mellanby Centre for Bone Research, The University of Sheffield, Sheffield, UK
Robin M. H. Rumney, Ankita Agrawal, Norain Ab Latif, Hamish Forrest, Holly R. Evans, Iain D. Huggins & Alison Gartland
Cellular Signal Integration Group (C-SIG), Technical University of Denmark (DTU), Lyngby, Denmark
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