An NHP for CCHF research | Lab Animal
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Crimean-Congo hemorrhagic fever (CCHF) is a neglected but widespread viral disease that’s transmitted to humans via ticks. There’s no vaccine available, nor a clinically relevant animal
model. Immunocompromised mice can model severe forms of the disease, but their use is limited by their immune deficiencies. But recently, a new immunocompetent model has been discovered that
could help future research.
A pilot study led by researchers at the NIH National Institute of Allergy and Infectious Diseases tested CCHF infection in three different nonhuman primate species. Cynomologous macaques
seemed most susceptible; follow-up testing with additional macaques revealed symptoms and signs of disease progression that paralleled those in human patients.
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