A l’origine d’une maladie rare, un intestin frileux et intolérant à ses propres bactéries - salle de presse de l'inserm
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PROTEASOMAL DEGRADATION OF NOD2 BY NLRP12 IN MONOCYTES PROMOTES BACTERIAL TOLERANCE AND COLONIZATION BY ENTEROPATHOGENS Sylvain Normand1, Nadine Waldschmitt1,2, Andreas Neerincx3, Julio
Martinez-Torres4, Camille Chauvin1, Aurélie Couturier-Maillard1, Olivier Boulard1, Laetitia Cobret5,6, Fawaz Awad5,6, Ludovic Huot1, Andre Ribeiro-Ribeiro4, Katja Lautz7, Richard Ruez1,
Myriam Delacre1, Clovis Bondu1, Martin Guilliams8,9, Charlotte Scott8,9, Anthony Segal4, Serge Amselem5,6, David Hot1, Sonia Karabina5,6, Erwin Bohn10, Bernhard Ryffel11, Lionel F. Poulin1,
Thomas A. Kufer 12 & Mathias Chamaillard1 1 University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille,
F-59000 Lille, France. 2 Technische Universität München, Chair of Nutrition and Immunology, 85350 Freising-Weihenstephan, Germany. 3 Department of Pathology, University of Cambridge, Tennis
Court Road, Cambridge CB2 1QP, UK. 4 Division of Medicine, University College London, WC1E 6BT London, UK. 5 Sorbonne Universités, UPMC Univ Paris 06, UMR_S 933, F-75012 Paris, France. 6
Inserm, UMR_S 933, F-75012 Paris, France. 7 Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany. 8 Laboratory of Immunoregulation, VIB
Inflammation Research Center, 9052 Ghent, Belgium. 9 Department of Internal Medicine, Ghent University, Ghent 9000, Belgium. 10 Interfakultaeres Institut für Mikrobiologie und
Infektionsmedizin, Eberhard Karl Universitat Tuebingen, 72076 Tuebingen, Germany. 11 CNRS, Orléans University, INEM, UMR 7355, F-45071 Orléans, France. 12 Department of Immunology, Institute
of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany. _NATURE COMMUNICATIONS_ : HTTPS://DOI.ORG/10.1038/S41467-018-07750-5 _ _