ENDOGENOUS ANGIOTENSIN STIMULATION OF VASOPRESSIN (AVP) IN THE NEWBORN LAMB
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Exogenous renin or anglotensin II (A II) infused peripherally or into the CNS will stimulate thirst and AVP release. Whether the endogenous renin-anglotensin system physiologically
stimulates thirst or AVP secretion is unknown. To assess the effect of endogenous renin-angiotensin stimulation on AVP secretion in the lamb, nine normal newborn lambs were stimulated with
furosemide (FU) 2 mg/kg infused I.V. alone, and with the A II inhibitor 1-sar, 8-ala, A II, 5 μg/kg/min. Six anephric lambs received only FU. Blood samples were drawn at 8, 20, 35, 65 and
125 min. post infusion. PRA (ng/ml/hr), aldosterone (aldo, ng/dl) and AVP (μU/ml) were measured by RIA. (M and SEM) PRA increased within 8 min. from a baseline of 16.7±5.0 to 30.2±12.3 (p