328 theophylline metabolism by the human premature infant
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ABSTRACT The excretion of theophylline and its metabolites was studied in 8 premature infants treated for apnea. Changes and differences in metabolic patterns were sought. Theophylline and
metabolites were assayed in urine and serum by HPLC. Urine was passed through a Dowex-2 column for clean-up prior to injection. Recovery of compounds by this method was >95%. In 6
patients, multiple 6 hour urine specimens were assayed. Theophylline accounted for 62% of the total drug and metabolites excreted. The range was 54 to 95%. 1,3 dimethyluric acid (13DMU), the
predominant metabolite in adults, accounted for 22% of the excreted drug. 1-methyluric acid and 3-methylxanthine comprised the remainder, although caffeine was not quantitated. In 3
patients, there was a shift to a larger percentage excretion of 13DMU during therapy suggesting a development of metabolizing capacity. Dosage change in one patient resulted in no change in
metabolite pattern. Differences between patients may be the result of genetic variability or prenatal xenobiotics for which information was incomplete in this study. ARTICLE PDF AUTHOR
INFORMATION AUTHORS AND AFFILIATIONS * Virginia Commonwealth Univ., Medical College of Va., Depts of Pediatrics and Pharmacy, Richmond, Va. Lorne K Garrettson, John L Noles & Gilberto E
Rodriguez Authors * Lorne K Garrettson View author publications You can also search for this author inPubMed Google Scholar * John L Noles View author publications You can also search for
this author inPubMed Google Scholar * Gilberto E Rodriguez View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and
permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Garrettson, L., Noles, J. & Rodriguez, G. 328 THEOPHYLLINE METABOLISM BY THE HUMAN PREMATURE INFANT. _Pediatr Res_ 15 (Suppl 4), 494
(1981). https://doi.org/10.1203/00006450-198104001-00339 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00339 SHARE THIS ARTICLE Anyone you
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